Nuclear Pore Complex Structure, Conservation and Plasticity
نویسندگان
چکیده
منابع مشابه
The structure of the nuclear pore complex.
In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and translation in the cytoplasm imposes the requirement of transporting thousands of macromolecules between these two compartments. Nuclear pore complexes (NPCs) are the sole gateways that facilitate this macromolecular exchange across the nuclear envelope with the help of soluble transport receptors. ...
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Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins. In this Cell Science at a Glance article and the acco...
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Javier Fernandez-Martinez1,7, Seung Joong Kim2,7, Yi Shi3,7, Paula Upla4,7, Riccardo Pellarin2,6,7, Michael Gagnon5, Ilan E. Chemmama2, Junjie Wang3, Ilona Nudelman1, Wenzhu Zhang3, Rosemary Williams1, William J. Rice4, David L. Stokes4, Daniel Zenklusen5, Brian T. Chait3,*, Andrej Sali2,*, and Michael P. Rout1,* 1Laboratory of Cellular and Structural Biology, The Rockefeller University, New Yo...
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Nuclear pore complexes (NPCs) perforate the nuclear envelope and allow the exchange of macromolecules between the nucleus and the cytoplasm. To acquire a deeper understanding of this transport mechanism, we analyse the structure of the NPC scaffold and permeability barrier, by reconstructing the Xenopus laevis oocyte NPC from native nuclear envelopes up to 20 Å resolution by cryo-electron tomog...
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Nuclear pore complexes (NPCs) are gateways for nucleocytoplasmic exchange. To analyze their structure in a close-to-life state, we studied transport-active, intact nuclei from Dictyostelium discoideum by means of cryoelectron tomography. Subvolumes of the tomograms containing individual NPCs were extracted in silico and subjected to three-dimensional classification and averaging, whereby distin...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.081